TAMF 2024 Symposium Schedule

A Zone for Dialogue: Advancing Understanding and Treatment of Neuroimmune Psychiatric Disorders such as PANDAS and PANS

Recognizing and Treating PANDAS/PANS

8:00 – 9:00 (Registration) – Coffee, Tea, and assorted bakery goods

9:00 – 9:15 Welcome ~ Susan Manfull, PhD

9:15 – 10:00 Recognizing and Providing Early Treatment of PANDAS/PANS ~ Jennifer Frankovich, MD, MS, Juliette Madan, MD, MS, and Richard Morse, MD

• Distinguishing primary psychiatric disorders from PANDAS/PANS
• Overview of evidence for inflammation (low grades systemic), suspected triggers, clinical course, acute vs sub-acute, novel autoantibodies
• Treatment strategies
• Case examples

10:00 – 10:30 Triggers of Neuropsychiatric Deteriorations: What keeps an infectious disease doctor up at night? ~ Mark Pasternack, MD

10:30- 10:50 BREAK

10:50 – 11:20 Advanced Treatments: Steroids, Plasmapheresis, IVIG, and Rituximab ~ Beth Latimer, MD

11:20 – 11:50 A Primer on PANS in Primary Care: Best Practices and Barriers ~ Melissa McCormack, MD, PhD

11:50 – 12:45 Young Adult Panel Discussion: The Person at the Center of the Illness ~ Moderated by Daniela Sosa-Sarkar, PsyD

12:45 – 1:30 LUNCH

1:30 – 2:15 Clinical Panel ~ Juliette Madan, MD, MS, Richard Morse, MD, Jennifer Frankovich, MD, MS, Kyle Williams, MD, PhD, and Tim Ubhi, MD, Beth Latimer, MD

2:30 – 3:00 AUTISM, EPILEPSY, AND AGGRESSION: How are they related to PANS? ~ John Gaitanis, MD

3:00 STRETCH and SNACK

Research Advancements

3:15 – 5:15 Lightning Rounds ~ Moderated by Richard Morse, MD

• Identification of key cytokines in the pathogenesis of OCD and PANDAS ~ Kyle WIlliams, MD, PhD; Lauren Breithaub, PhD; Dritan Agalliu, PhD, MS; and Earl Harley, MD
• Update on research on the blood brain barrier ~ Dritan Agalliu, PhD and Jennifer Frankovich, MD, MS
• Perspectives on genetics PANS/PANDAS ~ Herb Lachman, MD, PhD and Peter van der Spek, Prof. dr.Ing.
• Microglia activation in the setting of neuroinflammatory conditions ~ Pawel Kiela, DVM, PhD and Herb Lachman, MD
• Developing predictive diagnostics to map illness trajectories in Borrelia infection-associated chronic illness ~ Michal Tal, PhD
• Neuropsychiatric symptoms and Bartonella ~ Shannon Delaney, MD
• Acute onset neuropsychiatric conditions in children and adolescents following SARS-CoV-2 infection ~ Juliette Madan, MD; Mohamed Jasser, MD; and Abby Gauch
• Epidemiological evaluation of neuroimmune psychiatric conditions ~ Juliette Madan, MD
• A report from the POND Brain Bank ~ Galam Khan, MD
• Wrap-up of Research Advancements ~ Richard Morse, MD

5:15 – 5:30 Closing Remarks ~ Juliette Madan, MD; Jenny Frankovich, MD; and Susan Manfull, PhD

Accreditation:
In support of improving patient care, this activity has been planned and implemented by Dartmouth Health and the Alex Manfull Fund. Dartmouth Health is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.

American Medical Association (AMA)
Dartmouth Health designates this live activity for a maximum of 7.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Learning Objectives:
At the conclusion of this learning activity, participants will be able to:

• Identify the clinical features of Neuroimmune Psychiatric disorders, specifically Pediatric Acute Onset Neuropsychiatric Syndrome (PANS) and Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS), emphasizing the critical role of primary care providers in diagnosis and management.
• Enhance skills in recognizing, treating, and appropriately referring individuals with PANDAS/PANS to improve patient outcomes.
• Discuss the latest research findings in Neuroimmune Psychiatry, including strategies for differentiating primary psychiatric disorders from PANDAS/PANS.