The research investigates TH17 lymphocytes’ impact on microglial and endothelial cell responses, linking mouse model findings to human conditions. It highlights significant cytokine and chemokine differences in patient samples, indicating microglial activity and blood-brain barrier damage. A 3D human brain barrier model shows changes in astrocyte activity and neuron morphology due to patient serum. Future studies will delve deeper into cytokines’ roles in neuroinflammatory diseases.
Presentation 8-B: Lightning Rounds – Update on Research on the Blood Brain Barrier
Updated: July 23, 2025 by bmanfull@comcast.net
The research investigates TH17 lymphocytes’ impact on microglial and endothelial cell responses, linking mouse model findings to human conditions. It highlights significant cytokine and chemokine differences in patient samples, indicating microglial activity and blood-brain barrier damage. A 3D human brain barrier model shows changes in astrocyte activity and neuron morphology due to patient serum. Future studies will delve deeper into cytokines’ roles in neuroinflammatory diseases.
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