Microglia play crucial roles in neuroinflammatory conditions, with their activation linked to gut microbiota. Dr. Pawel’s research focuses on autoimmune diseases, detailing microglial functions and their polarization into M1 and M2 types. Findings from metabolomic analysis show differences in metabolites between PANDAS patients and healthy controls. Experiments assess nitric oxide production in microglia, revealing insights into gene expression and the impact of endotoxin, guiding future research on circulating factors in PANDAS patients.
Presentation 8-D: Lightning Rounds – Microglia Activation in the Setting of Neuroinflammatory Conditions
Updated: July 23, 2025 by bmanfull@comcast.net
Microglia play crucial roles in neuroinflammatory conditions, with their activation linked to gut microbiota. Dr. Pawel’s research focuses on autoimmune diseases, detailing microglial functions and their polarization into M1 and M2 types. Findings from metabolomic analysis show differences in metabolites between PANDAS patients and healthy controls. Experiments assess nitric oxide production in microglia, revealing insights into gene expression and the impact of endotoxin, guiding future research on circulating factors in PANDAS patients.
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